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제     목 ThalesNano NEWSletter
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ThalesNano Inc.
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241st ACS

27-31 March, 2011
Anaheim, CA, USA
Booth #446
ThalesNano & Mettler-Toledo AutoChem, Inc. Joint workshop at ACS
Enabling and Optimizing Chemical Reactions in Real Time

28 March, 2011
3:30 - 6 PM
Room: 211 B
Click here to register for the workshop
1st International Conference of the Flow Chemistry Society

28-29 March, 2011
Munich, Germany
Booth #2

Flow Chemistry Congressunder the auspicies of The Flow Chemistry Society

28-29 April, 2011
Boston, MA, USA
Booth #6
In this issue...
First O-Cube Flow Ozonolysis Publication Online
Exciting New Chemistry on ThalesNano Systems
ThalesNano Flow Chemistry Seminar and User Group Meeting
ThalesNano Open Lab
ThalesNano Newsletter

Dear Colleague,

In this edition of the ThalesNano Newsletter we will focus on the following topics: 

  • ThalesNano to launch new product at Spring ACS in Anaheim.
  • Our Hydrogenation Academy
  • Debenzylation and Nitro Group Reduction of Diazepin Derivates
  • Reductive Amination in X-Cube

 ThalesNano To Launch Exciting New Product At ACS 


ThalesNano will once again be exhibiting at the Spring ACS in Anaheim at booth no. 446. ThalesNano will use this show to launch an exciting new flow reactor to the chemistry world. No details will be released until the first day of the conference, so make sure you come by the booth for more details.


ThalesNano will also be teaming up with Mettler-Toledo AutoChem, Inc. at the ACS to hold a workshop titled: Enabling And Optimizing Reactions In Real Time.

The topics that will be discussed during the workshop are:


  • Reactions with hazardous gases in a safe and controlled manner using flow.
  • An overview of FTIR analysis in industry.
  • Chemistry examples showing the rapid optimization of reactions using the combination of flow technology and inline analysis.
  • The potential for inline FTIR technology to be used as a PAT in API production.
  • Ideas for the future of flow chemistry and inline analysis (discussion).

It is free to attend and will be held on Monday 28th March at 3:30 - 6 PM (room 211 B). Free food and drink will be provided after the seminar. The online ACS registration for this event is now closed, so please visit the booth on Monday to register.


ThalesNano's Hydrogenation Academy


For safety reasons the vast majority of US universities do not currently offer any practical experience of hydrogenation to their undergraduate students despite the fact that this reaction accounts for between 5-15% of reactions performed in industry. This means your students are missing out and will not be fully prepared when going out into industry. ThalesNano's H-Cube® family of products allows a diverse range of scientifically interesting hydrogenation reactions to be run at high speeds and in total safety.


The ThalesNano Hydrogenation Academy is designed to give academic institutes the opportunity to re-introduce hydrogenation to the teaching laboratory offering a comprehensive teaching package incudes training videos, presentation and a full laboratory notebook.


           Hydrogenation Academy


If you are interested in how to integrate hydrogenation into your practical laboratory sessions, then please visit our website at the Hydrogenation Academy.

Debenzylation and Nitro Group Reduction of Diazepin Derivates 

J. Spencer et al. have published a paper titled Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity in Bioorganic & Medicinal Chemistry. In the paper, the H-Cube was successfully used to remove a benzyl group and nitro group reduction using 10% Pd/C and Raney Ni as catalyst respectively. 








The above reaction was carried out in an H-Cube using full hydrogen mode, 40°C, and a flow rate of 1 mL/min. 3.06 mmol of crude product from an alkylation reacton was used as starting material in EtOH/AcOH (7:3). The reaction resulted in a product yield of 83% after flash chromatography.


For more information please click here.



Reductive Amination in X-Cube


Recently a novel publication in Tetrahedon Letters detailed a reductive amination process under both batch and flow conditions. Using flow methodology, similar or higher yields of amines were obtained in half the time on the X-Cube compared to the corresponding batch reactions. One example of the experimental series showed a 68% yield in flow, compared to 60% in batch, using 10% Pd/C catalyst, 6 equ. HCOONH4 , and MeOH at a temperature of 40°C (RT in batch). A flow rate of 0.2 mL/min was used.



 For more information please click here.

Contact us

If you have any questions about the above, then please feel free to contact us at flowchemistry@thalesnano.com

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